Here, the presence of survivin in more aggressive and poorly differentiated variants of oral SCC confirms and extends earlier reports of survivin expression in skin cancers (Chiodino et al, 1999; Grossman et al, 1999b), and suggests its potential predictive/prognostic impact for disease progression.
Only one case in our study (case 20, which harbored a somatically-acquired LKB1 mutation) was diagnosed as a minimal-deviation adenocarcinoma (MDA), a rare, extremely well-differentiated variant of cervical adenocarcinoma associated with Peutz-Jeghers Syndrome [18].
Due to its similarity in growth rate and morphology to rapidly growing well differentiated SCCs (Billingsley et al, 1999) some authors believe it is a well-differentiated variant of cutaneous SCCs (Manstein et al, 1998) or at least an 'abortive malignancy, which only rarely progresses into Schwartzhwartz, 1979).
Children tend to have the poorly differentiated histologic variant of the disease, which is associated with increased locoregional spread and distant metastasis.
Their milk exists in a majority of differentiated variants, and they drink it like water.
MUC5B and MUC6 were detected in the mucin lakes of mucinous differentiated variants.
On the contrary, the keratinizing and the nonkeratinizing differentiated variants (WHO I and II, respectively) account together for 50%75%% of NPCs in the United States [ 2].
We, first, identified a 170-gene classifier of six major subtypes (Figure 2) that frequently pose differential diagnosis problems, as they can all present with pleomorphic poorly differentiated variants.
Protomyofibroblasts evolve in most cases into differentiated myofibroblasts, the most common variant of this cell, with stress fibers containing α-smooth muscle actin (for review, see [ 5]).
