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Mixl1GFP/w cells were differentiated until d3 in the presence of BMP4 or Wnt3a (both added at d1) or Activin A (added d2).
1 Breast epithelial cells do not become fully differentiated until after the first full term pregnancy.
Indeed, functional hepatocytes are not terminally differentiated until very late in life, a fact that correlates with progressive reduction of their proliferating potential [ 31, 32].
Fruit bearing was observed from May, when inflorescences first differentiated, until July or even later (Additional file 2: Figure S1).
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The branching ductal architecture develops postnatally in response to hormone stimulation during puberty, but does not reach a fully differentiated state until pregnancy and lactation when hormones stimulate the proliferation and differentiation of terminal ductal lobular units that contain many alveoli.
It continued at differentiated speeds until the 1970s, reaching a total volume of six million, with a partial reversal after that.
Despite recent studies having raised doubts about whether to consider this taxon as a species or as a variety of M. atropurpureum (Espert et al. 2007), we decided to treat it as a differentiated entity, until further analysis corroborates its status.
Keratinocytes, arising from basally located stem cells, accumulate proteins during their differentiation until they reach the most differentiated apical layer, the stratum corneum.
Another possibility is that Delta-1 could function to keep selected neuronal progenitors in a pre-differentiated state until rostral differentiating gradients (i.e. retinoic acid) reach them.
Primary HBE cells were differentiated in culture until they became ciliated.
The intestinal stem cell-derived epithelial cells are proliferating until terminally differentiated.
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