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Categorizing according to differentiation, well differentiated type was 5%% (4 of 73 patients) and moderately differentiated type was 30%% (3 out of 10 patients). .
But Liu et al. reported that overall 5-year survival rate was 77.3 % for the well-differentiated type and 76.7 % for the moderately differentiated type, which was not statistically significant [6].
Geum et al. reported that the disease-specific 5-year survival rate was 94.7 % for the well-differentiated type, 57.1 % for the moderately differentiated type, and 25.0 % for the poorly differentiated type related to survival rate of oral squamous cell carcinoma according to histopathological differentiation [22].
Conversely, expression of aquaporin 5 (aqp5), a terminally differentiated type I cell marker, was reduced in Cby−/− lungs.
Fibrosis is driven by soluble mediators from differentiated type 2 immune response [34] including Il-4, Il-13 and TGF- β[35], [36].
The moderately differentiated type was most frequently present, as it was noted among 37 patients (63%), followed by the well-differentiated type found in 13 patients (22%), and the poorly differentiated type occurred among seven patients (12%).
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Expression of hENT1 expression is associated with a well-differentiated type of tumor [17].
Grade was originally coded as three types (according to the Tumor-Node-Metastasis (TNM) classification [51]): type 1 (well-differentiated), type 2 (intermediate) and type 3 (poorly-differentiated).
The histopathological grade was usually squamous cell carcinoma of a well-differentiated type.
Sporadic NPC is usually of the well-differentiated type whereas familial disease is poorly differentiated (McDermott et al, 2001).
It is plausible that MKRN1 is involved in carcinogenesis of the well-differentiated type of tumors possibly via ubiquitination of L-FILIP.
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