Overexpression of exogenous fate-specifying transcription factors can directly reprogram differentiated somatic cells to target cell types.
It also implies that anti-cancer therapy should shift from attempts to eliminate the bulk of rapidly dividing and terminally differentiated cells to targeting T-ICs within a tumor.
To test whether one of the reasons for increased tumour initiation was due to an expanded cell of origin population they used the Xbps1-CreER to target differentiated cells in the intestine.
From the therapeutic point of view, γ-T3 has the potential to be an effective drug to target both differentiated cancer cells and CSCs, which is better than conventional chemotherapeutic drugs that only target differentiated cancer cells.
In our previous studies, we have demonstrated the ability of scL to target both CSCs and differentiated bulk tumor cells in GBM xenografts using multiple markers of CSCs including CD133, SSEA-1, Nestin, Nanog, and Msi1.
Hence, it may be desirable to target CD133+ tumours that are of the poorly differentiated stage rather than well-differentiated tumours with apically expressed CD133.
It is important when performing biopsy to target the soft tissue component of the tumour, as these are frequently the poorly differentiated component [53].
The instrumentation of REACH is differentiated and targeted to this complex regulatory field.
Diversity marketing became a staple for brands to create clear and differentiated strategies for targeting consumers of African-American, Hispanic and Asian ethnicity.
As Ctn1 (which shares 85% sequence homology with Ctn2) is restricted to differentiated cells, we targeted Ctn2, which is ubiquitously expressed at the centrioles of all somatic cells (Salisbury et al., 2002; Salisbury, 2007).
In one model, a DC-based vaccine prevented the outgrowth of a spontaneous breast tumour in a mouse model when used to specifically target a single differentiated tumour antigen, HER-2/ neu [ 92].
