As an example, conditional mice with Tsc2 gene inactivation in differentiated astrocytes have been shown to display a more severe phenotype than those with Tsc1 deletion (Zeng et al., 2011).
Thus, undifferentiated gastric cancer cells were more likely to display positive Nrf2 immunoreactivity compared to differentiated gastric cancer cells.
An average of four days was required to display cells with neuron-like characteristics, and ten days to obtain more than 70 80% of differentiated BM-MSC.
In case of development and differentiation, differentiated cells display a stable, cell-type-specific methylation pattern, permanently switching off the expression of genes that are not essential for the respective cell type.
Clinical findings indicated that Src activity is highest in moderate to well-differentiated colonic lesions, whereas poorly differentiated carcinomas display Src kinase activity similar to normal colonic mucosa.
Thus, these data are consistent with the in vivo observations of the CD44+CD24− cells differentiating into the heterogeneous cells present in the parental LNCaP cell line and demonstrate that CD44+CD24− LNCaP stem cells can give rise to differentiated cells that display different surface markers.
However, chondrocyte differentiated BMSCs display an endochondral phenotype, that is, can terminally differentiate and form a calcified matrix, leading to failure in long-term defect repair.
Differentiated VSMCs display contractile properties, whereas undifferentiated VSMCs are proliferative (Owens, 1995).
It is well established that embryonic stem cells (ESCs) and fully differentiated cells display widely different genomic methylation patterns [ 14].
Differentiated neurons display specific biochemical, physiological and morphological properties that apparently prevent them from further cell division.
