It functions as a scaffold for tissue morphogenesis, provides cues for cell proliferation and differentiation, promotes the maintenance of differentiated tissues and enhances the repair response after injury.
miRNAs post-transcriptionally downregulated SIRT1 during mESC differentiation and maintained low levels of SIRT1 expression in differentiated tissues.
For that matter, it might be nice to be unicellular: after all, cancer arises because our differentiated tissues run amok.
The implantation of a cloned embryo into an artificial uterus allows for the real possibility of harvesting differentiated tissues and fully formed organs from humans that have developmentally progressed to the fetal stage and beyond.
The human embryonic stem cells form a wide variety of differentiated tissues in vitro, and they form teratomas when grafted into immunosuppressed mice.
Type XIV collagen is predominantly expressed in differentiated tissues and late embryonic development.
Especially, the members of Laminariales (so-called kelps) have developed highly differentiated tissues.
Adult stem cells are undifferentiated cells, which reside in differentiated tissues.
W1, W2 and W3 genes are induced in differentiated tissues, while W4 genes are up-regulated in neoblasts.
Hence, its application in vivo would result in expression of a cloned gene in undifferentiated and differentiated tissues.
Telomerase activity has been found in most cancer cells, but not in the majority of normal differentiated tissues.
