Less differentiated tissue engineered cartilage implants (re-differentiated for five days) demonstrated better integration properties compared with mature implants (re-differentiated for five weeks).
Functional studies of the mammary mesenchyme have demonstrated its profound role in directing and maintaining normal mammary tissue differentiation and architecture; mammary mesenchyme can restore some features of differentiated tissue to mouse mammary tumours when grown together in culture [ 54].
Dedifferentiation, as a universal biological phenomenon, involves the regression from a specialized differentiated tissue to a stem cell-like state with retained self-renewal properties.
Implantation of long-term differentiated tissue constructs in nude mice resulted in further development and maintenance of fat pads.
If embryonic stem cells are grafted into an adult mouse, they will develop into a type of tumour called a teratoma, which contains a variety of differentiated tissue types.
These replacement tissues are being realised through the use of biodegradable polymer scaffolds; temporary/permanent substrates, which facilitate cell attachment, proliferation, retention and differentiated tissue function.
Both DPPSCs and differentiated tissue showed normal chromosomal dosage after being cultured in vitro and analysed using short-chromosome genomic hybridisation (short-CGH).
Thus factors which generate and maintain accessible chromatin during development, and in fully differentiated tissue, contribute a major fraction of receptor tissue specificity.
Myogenic and osteogenic cell potential are highly reliant on the elastic modulus of the starting cell population (of undifferentiated cells), and this potential appears to peak when the innate cell elastic modulus is close to that of differentiated tissue.
Benfey, PN, Defining the Path from Stem Cells to Differentiated Tissue., Current Topics in Developmental Biology, vol. 116 (January, 2016), pp. 35-43 [abs] [abs].
For example, determining whether the MI is acute or chronic, hemorrhagic or non-hemorrhagic, as well as the quantification of differentiated tissue types are all evaluations afforded by in vivo TCM.
