According to the definition of tumour cell dedifferentiation in this study, 21 patients (14%) showed both well or moderately differentiated at the surface to the centre and poorly differentiated at the margin in patients with predominantly differentiated histology (n=153).
A certain number of GCs with such mixed histology show both low or intermediate grade (well/moderately differentiated) at the surface to the centre and a high grade (poorly differentiated) at the invasive front of the tumour.
Among GC with co-existence of several histologic elements, one form of GC with mixed histology exists, which shows both low or intermediate grade (well/moderately differentiated) at the surface to the centre and a high grade (poorly differentiated) at the invasive front of the tumour.
Here, we have designed a compartmented set-up where model neural cells are differentiated on the surface of Aβ-containing collagen matrices.
Transcripts for Wnt5a, a Frizzled receptor binding protein exclusive to the PCP pathway, were detected in the lens placode, which was clearly differentiated from the surface ectoderm and perioptic vascular plexus (Fig. 2C).
We show that these two subsets of CD8 T cells can be differentiated based on the surface expression of CD122 (IL-2 Rβ chain).
In CIN1, intense membrane staining covered two-thirds of the epithelial thickness, and in the differentiated cells of the surface the staining was weak or absent.
Study on primary rat colonocytes has shown that cells from lower crypt sections are more sensitive towards hydrogen peroxide damage than differentiated cells at the surface of the crypt [ 29].
Reendothelialization after vascular injury results either from local recruitment of adjacent endothelial cells [ 10] or from adhesion of blood-derived endothelial progenitor cells (EPCs) that differentiated and populate the surface of the stent [ 11].
When one cell type was differentiated, the most consistent and striking observation was that differentiated cells sort to the surface and form an enveloping layer regardless the relative cell adhesive affinity of any combination in the chimeric embryoid bodies, further substantiating our previous finding (Moore et al., 2009).
