Additionally, cancers of all stages located in the proximal colon lacking PTEN expression were more frequently poorly differentiated than those that were in the distal colon or rectum (p < 0.01).
Immunohistochemical analysis revealed that the level of MSK1 phosphorylation at Thr581 was significantly higher in the poorly differentiated NPC tissues than that in normal nasopharynx tissues (P < 0.001).
As shown in Table 1, the level of MSK1 phosphorylation at Thr581 was significantly higher in the poorly differentiated NPC tissues than that in normal nasopharynx tissues (χ = 15.137, P < 0.001).
The vast majority of ER + breast cancers are clearly also AR + (84 to 91%) [ 5, 37, 38] and patients with tumors that co-express AR with ER and PR have a longer DFS than those with tumors negative for all three receptors [ 37], probably reflecting a more well-differentiated state than that of receptor-negative tumors.
Immunohistochemical analysis revealed that the expression of p-H3Ser10 was significantly higher in the poorly differentiated NPC tissues than that in chronic nasopharyngitis (p <0.05) and normal nasopharynx tissues (p <0.001).
As shown in Figure 1 and Table 1, p-H3Ser10 positive labeling index was significantly higher in the poorly differentiated NPC tissues than that in chronic nasopharyngitis tissues (p<0.05) and normal nasopharynx tissues (p<0.001).
In undifferentiated cells, only the treatment with 5 μ m 27-OH showed a statistically significant but moderate increase (+50%) in Aβ1-42; conversely, 1 μ m 27-OH, 1 and 5 μ m 24-OH did not affect the Aβ constitutive amount which is relatively lower than that found in differentiated control cells.
P53 positive immunosatining rate in well-differentiated GC was lower than that in poorly-differentiated GC (p = 0.012, Table 2).
Stem cells exhibit different metabolic properties than their differentiated progeny that may promote 'stemness'stemness
Well-differentiated tumors are generally less advanced and support a better prognosis than poorly differentiated tumors that are more aggressive and correlate with poorer prognosis.
