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An alternative explanation for this may be that for some reason, the GFP− HSCs might have died or differentiated such that the GFP+ cells became a higher proportion of the total HSC population.
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Pathological assessment of tissues showed that tumors were in different states of differentiation, such that 32 (71%) cases were poorly differentiated, 5 (11%) were moderately differentiated and 8 (18%) others were well differentiated.
A higher KLRG-1 expression level in the direct ex vivo stains has typically been associated with more terminally differentiated cells, such that the differential expression of KLRG-1 marks the diverse memory and death fates of the effector CD8 T cells.
The exciting possibility exists that boosting stem cell responses simultaneously in multiple tissues will actually rejuvenate the differentiated cells, such that over time less and less intervention will be needed and the intrinsic age-imposed changes in the differentiated soma would be broadly attenuated or possibly reversed [ 3].
In the future, we plan to expand our implementation by improving the data delivery mechanism to incorporate differentiated priority scheduling, such that higher priority traffic can be transmitted in preference to lower priority traffic.
Chromosome replication generates differentiated sister chromatids such that one specific member of the two is imprinted.
The degree of cellular heterogeneity in moderately differentiated SCCs was such that morphologically identical squamous cancer cells could be distinguished on the basis of TA-4 expression.
This approach enables discrimination between cells in the same lineage but at different stages and between cells that have differentiated, such as the differentiation of human monocytes into macrophages or dendritic cells (DCs) [2].
The design of both the hardware and software is modular, general and flexible such that differentiated products can easily be generated for applications in niche fields within a short development window.
Adipocytes were differentiated prior to incubation in PM-M microplates, such that >90% of cells contained lipid droplets.
DOI: http://dx.doi.org/10.7554/eLife.00960.005 Heterotypic cooperation can occur between populations that are genetically related but phenotypically differentiated, such as between different cell types in a multicellular organism.
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CEO of Professional Science Editing for Scientists @ prosciediting.com