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If so, future efforts should be directed toward isolating and expanding less differentiated subsets of T cells with greater pluripotency.
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He has been instrumental in discovering the molecular basis of T-cell differentiation from precursor cells into differentiated subsets.
The CD80high mTECs constitute the most differentiated subset, present the largest repertoire of MHC-ligands to developing T cells and are also able to transfer antigens to thymic dendritic cells (DCs) for cross-presentation.
This suggests a difference in time of occurrence of 16q LOH in these two morphological distinguishable groups, ie early LOH in well differentiated tumours and late (upon invasion) in the poorly differentiated subset.
The Hospicells might therefore represent a differentiated stromal subset of the mesenchymal stem cells.
These data suggest that in the mouse embryo Lim-1 plays a role in early mesoderm formation and later specification of a differentiated phenotype in subsets of cells of the mesonephros and sensory neurons of the CNS.
EAAT1 and EAAT2 are expressed in discrete and partially overlapping subsets of differentiated glia in Drosophila (Rival et al., 2004; Soustelle et al., 2002).
In addition, a functional role of lipid rafts may not be the same in distinct subsets of differentiated CD4+ T cells.
The DRG neurons and subsets of differentiated interneurons in the dorsal spinal cord were also TLX3-positive, as reported previously [ 62], however, these cells appeared normal in Six1/4 EGFP/EGFP (n = 6, Figure 4C,D).
We extended this analysis to identify two smaller subsets of differentiated-committed and intermediate mESCs and a larger self-renewing population.
The introduction of metronomic capecitabine could account for the high response rate obtained in this well-differentiated subset.
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