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Rb is known to be required for myogenic differentiation but not for the maintenance of the terminally differentiated state in myotubes (Huh et al., 2004).
These data suggest that the PKC epsilon isoform may be important for the production and maintenance of the differentiated state in NG 108-15 cells.
The miRNAs found to be expressed in both astrocytes and neurons are perhaps involved in maintenance of the terminally differentiated state in both cell types.
Down-regulation of the key regulator of adipogenesis, Pparg, indicated modulation of differentiated state in adipose tissue, as revealed by GSEA analysis.
With these maps of the differentiated state in place, a central task is now to unravel the chromatin dynamics that enables these differentiation transitions.
The down-regulation of Pparg also indicates the modulation of markers of the differentiated state in adipose tissue, as indicated by the GSEA analyses.
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From these results, the cell morphologies on the CL surface and in the CL gel were proposed as indicators for understanding chondrogenic potentials concerning the phenotypes and differentiated states in the population during cell expansion, ultimately leading to quality control of tissue-engineered cartilage.
This could be used to transmit determined and differentiated states in cell lineages [8].
For example, the evolution of quiescence-promoting genes presumably was required for the evolution of differentiated states in metazoan tissues, where cells no longer divide.
We identified a striking genetic similarity of the two cell populations that, indeed, strongly indicates a dynamic fluctuation of cancer cells between the CSC and differentiated states in vivo.
Indeed, defects in protein glycosylation machinery frequently lead to the impairment of developmental signaling, the retardation of embryogenesis in animal models and the pathogenesis of human congenital disorders, highlighting alternative mechanisms by which protein glycosylation may regulate pluripotent and differentiated states in hPSCs.
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