In vitro differentiated SHIP-1−/− Th2 cells produced less IL-4 compared to wild type Th2 cells upon T cell receptor stimulation.
Increased MKP compartment without a proportional increase of more differentiated MK and platelets in SHIP deficient mice may support the hypothesis that early megakaryocytopoiesis and late megakaryocyte development and platelet shedding may be regulated by distinct mechanisms.
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Without TCR stimulation undifferentiated Th0 cells and differentiated Th2 cells from WT and SHIP-1−/− mice did not produce any detectable levels of IL-4 or IFN-γ (Figure 7).
In contrast, the total number of differentiated megakaryocytes (Lin−c-Kit−CD41+ MK) was unaltered in SHIP deficient mice.
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To further characterize the megakaryocytic compartment in SHIP deficient mice, we assessed the presence of early MKP, immuno-stained as Lin−c-Kit+CD41+, and of more differentiated MK, identified as Lin−c-Kit Lin−c-Kitigure 2A) [34].
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"Selectively differentiated," the librarian offered.
