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In the mouse skin, miR-203 expression is only detectable in the suprabasal layers and the differentiated sheets of mature hair follicles.
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We postulated that implanting sheets of differentiated urothelium would establish more rapid, effective barrier function and noted reduced urothelial CK14 expression and fewer lymphocytes in the subaugment stroma of bladders reconstructed with differentiated urothelium.
The results showed that pleura and subpleural regions of the lungs were infiltrated with sheets of poorly differentiated neoplastic cells demonstrating that bioluminescent imaging can effectively detect micrometastases in a mouse (Figure 4C,D).
Tumors showed abnormal ducts containing secretory products separated by sheets of poorly differentiated epithelial cells.
Histological examination of the H&E sections showed that the primary xenografts were adenocarcinomas with features similar to the original surgical specimens, with the exception of OIP17 that grew as sheets of poorly differentiated cancer cells.
Higher-grade endometrioid adenocarcinomas have less well-differentiated cells, have more solid sheets of tumor cells no longer organized into glands, and are associated with an atrophied endometrium.
Urothelium harvested by open biopsy was expanded in culture and used to develop sheets of nondifferentiated or differentiated urothelium.
Prostatic lesions under these conditions included well-differentiated adenocarcinomas with low proliferative index as well as large neuroendocrine tumours, composed of sheets of small, undifferentiated cells that stained intensely for the proliferation-associated marker, Ki-67 (Supplementary Figure 1).
Sheets of dust.
sheets of paper.
Get sheets of wood.
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