These findings provide some novel insights into gender-differentiated sensitivity to the environment, the role of timing and maturation on associations with adversities, the impact of emotionality on depressive symptoms over time, and the potential bidirectional effects between social and cognitive systems in the adolescent years.
Many tissue pairs could be differentiated with sensitivities and specificities of around 90%.
Vision of passerine birds is chiefly differentiated by the sensitivity maxima of the VS cone, with other cone sensitivities being similar.
They found that almost all tissue pairs could be differentiated with high sensitivity and specificity.
It has been suggested that differentiated cells show greater sensitivity than undifferentiated cells because DAT is highly expressed in differentiated cells.
Hence, the fact of having the first child at an early age may entail lower sensitivity of differentiated mammary tissue to the action of mitogens and mutagens.
LGDN, low grade dysplastic nodule; HGDN, high grade dysplastic nodule; WDHCC, welldifferentiated hepatocellular carcinoma; MDHCC, moderately differentiated hepatocellular carcinoma; Sen, sensitivity; Spe, specification; PPV, positive predictive value; NPV, negative predictive value.
However, limiting factors such as the variable expression of different epithelial antigens in poorly differentiated tumours, the different sensitivity and specificity of various detection assays, and the lack of their direct comparison support the need for cautious consideration of the use of CTC measurement in the daily clinical practice.
These results are consistent with previous findings that MGMT expression alone does not always predict the response to TMZ [21] and that MGMT status is only associated with TMZ sensitivity under differentiated conditions and not in stem-like cells under neurosphere conditions [22].
However, regarding the initial onset of neurogenesis in the ectoderm, we propose that NvAth-like is a key pro-neurogenic factor, due to its early expression in blastula stage embryos, its localisation in dividing (and thus pre-differentiated) cells, its early sensitivity to Notch signalling, and owing to the fact that knockdown of NvAth-like results in the development of fewer neural cells.
