Histological analysis revealed that the tumors developed by cen3tel cells at the first and second tumorigenic phases were pleomorphic sarcomas (Fig. 1B and C), those developed by phase III cen3tel cells showed a hemangiopericytoma-like vascular pattern, similar to human poorly differentiated, round-cell synovial sarcoma (Fig. 1D).
Primary and non-transformed prostate epithelial cells, but also several PrCa lines, formed well-differentiated round spheroids.
DAPI staining showed that LL-37-differentiated round adherent cells have a single nucleus in spite of their larger cell size (Figure 1C).
HE staining of G1 lesions revealed well-differentiated round or ovoid cells arranged in nests and glandular duct or chrysanthemum formation.
The histopathological diagnosis of the patient was reported as poorly differentiated malignant round cell tumor with metastasis in regional lymph nodes and perinodal extension.
WHO classification of liposarcoma is well differentiated, myxoid, round cell & pleomorphic types.
In addition to the spermatogonia also some more differentiated large round cells were also present, which eventually died.
According to the WHO classification, liposarcoma is divided into the following categories: well-differentiated, differentiated, myxoid, round-cell, pleomorphic, mixed-type liposarcoma, and liposarcoma, not otherwise specified.
Several subtypes exist, ranging from low- to high-grade malignancy (well-differentiated-, myxoid-, round cell-, pleomixedic-, mixed- and dedifferentiated-type liposarcomas).
