Gaddum first differentiated receptors responding to serotonin into two subtypes in the 1950s based on the contraction of smooth muscle or on the depolarization of the cholinergic nerves.
One possible explanation is that the poorly differentiated RMS respond better to chemotherapy than to well differentiated RMS.
Our previous work showed that, under our culture conditions, DUX4-FL was expressed from its endogenous promoter only in differentiated (MyHC-expressing) myogenic cells, 23 so it was important to determine if differentiated cells responded differently to DUX4-FL than myoblasts.
Furthermore, differentiated PASCs responded to stimulation with hypothalamic hormones and produced corresponding pituitary hormones that are reflective of the phenotypes of the primary pituitary tumours.
"Our relentless focus on real education is something that has differentiated us," he responds, when asked how pi-top stands out in what's now a very crowded marketplace.
As shown in Figure 4A, only cells differentiated from PASC1 responded to GHRF and LHRH and produced GH, FSH, and LH.
During pregnancy in the rodent, when PRL levels are known to be low, it is likely that differentiated expression levels respond to placental lactogens [ 37].
The lymphocytes present in peripheral blood have been utilized to detect γ -H2AX formation during cancer treatment, but these terminally differentiated cells may respond poorly to anticancer drugs that interfere with DNA metabolism.
To identify differentiated genes that responded to TNT treatment with various doses in vivo, One-Way ANOVA was performed across 5 doses at each time point (24 h or 48h).
10, 30, 31 The ability to completely eliminate GRP78 in the PCs through genetic knockout in the tipsy mice offers a unique opportunity to interrogate how a non-proliferating, terminally differentiated neuron responds to the complete loss of this UPR regulator.
