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Taken together, hES cell derived hepatic endoderm cells differentiated rapidly without extensive expansion.
Following staining, sections were differentiated rapidly in 95% alcohol, dehydrated and cleared through absolute alcohol and xylene and mounted with Permount (Fisher Scientific, Toronto, ON, Canada).
To overcome this limitation, we used LUHMES cells that can be differentiated rapidly and efficiently to biochemically mature dopaminergic-like neurons.
In the TRAMP model, Gamitrinib-G4, which contains a structurally distinct mitochondrial-targeting moiety compared with Gamitrinib-TPP (Kang et al, 2009), was active across the spectrum of poorly differentiated, rapidly proliferating neuroendocrine tumours, as well as of differentiated adenocarcinoma.
Poorly differentiated rapidly growing and moderately differentiated slowly growing human pancreatic tumours were implanted in the neck of nude mice that were orally treated or not with the inhibitor.
If the core differentiated rapidly (via rapid sinking of Fe° into the core), the early atmosphere may have resembled the composition of modern volcanic gases (Rubey 1951).
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Threatened species that are composed of highly differentiated yet rapidly declining are a challenge to conservation management.
To know why proteins of some metazoans multicellular animals with differentiated tissues evolve rapidly and some more or less stagnate for eons.
Overall, the effects of NVP-BEZ235 appear less dramatic in these models relative to those seen in xenograft established from cell lines (Maira et al, 2008; Serra et al, 2008), which are typically poorly differentiated and rapidly proliferating.
The life span of mature osteoclasts is relatively short both in vitro and in vivo, and once differentiated, they rapidly die in the absence of supporting cell or growth factors.
After partial hepatectomy (PH) or chemical-induced moderate liver injury, fully differentiated hepatocytes rapidly reenter the cell cycle and proliferate to restore the original liver mass without any contribution from hepatic stem/progenitor cells.
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