The taxonomically-differentiated proportion excludes the 'nei' (not elsewhere included) and generic 'sharks, rays, and chimaeras' category.
Biology-based tumor types were significantly associated with tumor grading: While HR+/HER2- positive tumors were most frequently well or moderately differentiated, the proportion of G3 tumors was higher in the HR-/HER2+ as well as HR-/HER- group (P = 0.004, χ2 test).
This suggests that higher expression of the M-phase and mRNA/ribosome synthesis signature could have been a result of lower proportions of more differentiated and higher proportions of less differentiated cells.
These tumours retain hallmarks of the normal epithelial terminal differentiation programme; however, proliferation is increased, the proportion of differentiated cells is decreased, and the spatial organisation of the cell layers is disrupted [1].
We observed that the addition of bFGF to the culture medium promotes the maintenance of a higher number of differentiated cells, reducing the proportion of progenitors within the whole population.
Expression of IGFBP-5.1 (Fig. 3C), IGFBP-5.2 (Fig. 3D) and IGFBP-6 (Fig. 3E) were high in mononuclear cells (2d) then declined as the culture matured and the proportion of differentiated myotubes increased (P<0.01).
The other two-locus combinations that exhibited a proportion of differentiated species pairs better than or equal to the best single locus were trnH-psbA+ITS1 (85.1%) and rbcL-a+matK (82.6%).
Like the full length mrTIMP-1 and its NT1 variant, 24 h of exposure to RXPO3R significantly reduced the length of neurites and increased the area of growth cones (Fig. 4B and C), without affecting cell viability or the proportion of differentiated neurons (not shown).
The trnH-psbA spacer when combined with either rbcL-a, rpoB2, or rpoC1 demonstrated the highest PCR primer success (100%, i.e., primers amplified for at least one if not both loci across all taxa) and the highest proportion of differentiated species pairs (87.5%; Table 4).
Total tau was expressed in a large proportion of differentiated WT RGs (Fig. 4E).
This lower proportion of differentiated cells is consistent with the increased pOPC proliferation induced by cuprizone.
