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Thus the elevated constitutive expression of Irga6 found in vivo appeared to reflect a differentiated property of hepatocytes that, in common with other differentiated functions of these cells, is lost on in vitro culture [19] [21].
Therefore, it was suggested that the genes in G2 can exhibit the specificity or differentiated property of hOFs.
Twenty-two genes in hOFs were expressed at lower levels than in hDFs that showed expression levels similar to those of hOF-iPSCs (hOFs < hDFs = hiPSCs; group G4), suggesting specificity or differentiated property of hOFs by suppression and, reciprocally, plasticity or undifferentiated property of hDFs.
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Thus, some, but probably not all, of the differentiated properties of these cells are a consequence of their cellular environment.
Consequently, a new requirement has arisen for cells in vitro that maintain the differentiated properties of their counterparts in vivo.
Lack of expression of the differentiated properties of the cells of origin is a major recurrent problem.
Having created different types of bacterial L-forms, we identified several common and differentiated properties, as summarized in Table 1.> -wrap-foot> (i) Growth conditions.
Recently it was shown that premalignant mammary epithelial cells exposed to senescent human fibroblasts in mice irreversibly lose differentiated properties, become invasive and undergo full malignant transformation (Parrinello et al., 2005).
The company has more than 180 patents, both issued and pending, covering its solutions, software and differentiated intellectual property.
Differentiated intellectual property with mass commercial application and broad market demand is difficult to come by in the world of Internet and software startups.
In spite of headwinds facing the company, analyst Jesse Pichel of Piper Jaffray notes that the company's "ongoing efficiency and cost improvements derived through differentiated intellectual property with entry barriers remain reasons to favor First Solar longer term".
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com