The loss of 16q thereby seems to represent the cytogenetic hallmark of the well-differentiated progression pathway, even though a subset of poorly differentiated tumours also revealed 16q-losses.
However, c-IRIS has to be differentiated from progression of the cryptococcal disease, although both phenomena can appear simultaneously [ 22].
Therefore, it appeared that while the non-transformed, bipotential HFH were surviving, a large proportion might be undergoing de-differentiation and/or progression towards a differentiated cholangiocyte upon engraftment, based on plasma albumin levels.
We also demonstrated that MBDA score differentiated patients without progression from those with progression better than CRP.
In addition, surgical procedures may cause increased contrast uptake which should be differentiated from tumor progression.
These results indicate that the STK1 protein assay, but not the STK1 activity assay, was capable of detecting well-differentiated cancer prior to its progression to poorly differentiated cancer.
It is well documented that HCC often undergo dedifferentiation (from well-differentiated to poorly differentiated) during multistep tumour progression (Mise et al, 1998), and that some HCC acquire metastatic potential during this progression, resulting in vein invasion (Hui et al, 1999).
Compared with higher non-tumoral GalNAc-T5 density in gastric epithelial cells, intratumoral GalNAc-T5 expression in gastric cancer cells decreased gradually accompanied with disease progression from well-differentiated adenocarcinoma, moderately differentiated adenocarcinoma, poorly differentiated adenocarcinoma to undifferentiated adenocarcinoma.
Neoplastic progression of differentiated somatic cells used for cell based therapy is a critical problem [4].
The aim of this study was to determine if CDKN2A gene products are implicated in differentiated thyroid carcinogenesis and progression.
Tumors negative for GATA3 and FOXA1 expression associate with poorly differentiated tumors and malignant progression [ 45, 46].
