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Importantly, the grafted CHI-treated cells differentiated predominantly into Pax3-positive somitic/paraxial mesoderm (Goulding et al., 1994), Snai2-positive lateral/ventral mesoderm (Sefton et al., 1998) and Pecam1-positive endothelia (Baldwin et al., 1994) (Fig. 5G).
Consistent with previous reports (Miyoshi et al., 2007), the majority of MGE cells transfected with the control vector dispersed throughout the cortex and differentiated predominantly into PV+ and (to a lesser extent) SST+ interneurons (65%and20%0%, respectively; Figures S2B S2B2, S2D S2D2, and S2F).
As shown in Figure 6a, cells from control mice differentiated predominantly into UCP1-negative adipocytes with large lipid droplets coated with Plin1.
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The typical patient presented with breast cancer in the upper outer quadrant, the tumor being moderately differentiated and predominantly of ductal histology.
In NSCLC patients, some studies have found that RASSF1A methylation correlates with poor survival rate and is associated with poorly differentiated tumours, predominantly with vascular invasion and pleural involvement [16,77,78] although others have found no such correlation [79 81].
We identified three themes that differentiated physicians who predominantly prescribe diuretics from those who predominantly prescribe other drug classes for the initial treatment of mild to moderate hypertension: a) perceptions about the efficacy of diuretics, b) preferred approach to hypertension management and, c) perceptions about hypertension guidelines.
We further found that well- and intermediately differentiated DCISs were predominantly ER positive and PR positive, while poorly differentiated DCIS usually lacked steroid receptor expression and was correlated with Her2 overexpression.
These themes differentiated physicians who predominantly prescribe diuretics as a first-line treatment of mild to moderate uncomplicated hypertension from those who predominantly prescribe drug classes other than diuretics: a) perception about the efficacy of diuretics, b) preferred approach to hypertension management, and c) perceptions about hypertension guidelines.
They maintained this level of cell cycle distribution after treatment, suggesting a predominantly differentiated state.
Our differentiated cultures were predominantly occupied by myotubes, showing a mature sarcomeric cross-striated pattern.
In patients with predominantly differentiated histology (n=153), prognostic values of tumour cell dedifferentiation and tumour budding were examined.
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