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Therefore, it is possible that the progression of the grade of differentiation is not sequential, but each differentiated portion is expanded from the common precursor region in these cases.
Furthermore, homozygous deletions were found only in poorly differentiated portion.
It is possible that moderately differentiated portion was progressed different from well- and poorly differentiated portions, and poorly differentiated portion was expanded from well-differentiated portion with accumulation of allelic loss at 3p25.
In cases 526 and 599, whereas the allelic pattern of the moderately differentiated portion differed from those of the well- and poorly differentiated portions, LOH or homozygous deletion was accumulated from the well-differentiated portion to poorly differentiated portion.
For example case 385, though LOHs at D3S1234 and D3S1274 were found in every differentiated portion, LOHs at D3S1597 and D3S1478 were found in moderately and poorly differentiated portions but not in well-differentiated portion.
It has been reported that accumulation of LOH occurred from high to lower differentiated portion (Yamasaki et al, 2000; Yatabe et al, 2000; Aoyagi et al, 2001).
Similar(51)
This implied that well-differentiated portion of this tumour was expanded from moderately differentiated portions with accumulation of LOHs at 3p21.3C and 3p14.2.
We defined that the BAC types were composed of a well-differentiated portion with the BAC pattern and moderately differentiated portions reminiscent of the BAC pattern.
For example case 423, though LOHs at D3S1597 and D3S1478 were found in well- and moderately differentiated portions, LOHs at D3S4622 and D3S1234 were found only in well-differentiated portion.
According to this classification, 23 primary lung adenocarcinoma samples included 17 well-differentiated portions, 19 moderately differentiated portions and 20 poorly differentiated portions.
We defined that well-differentiated portions were composed of the BAC or PAP pattern, moderately differentiated portions were composed of the PAP or acinar pattern and poorly differentiated portions were composed of the solid pattern.
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