We analyze the differentiated role played by traditional R&D determinants in driving research and development.
Differentiated chondrocytes play critical roles in endochondral ossification by producing factors such as Vegfa and IHH that signal to osteoblasts in adjacent perichondrium.
Differentiated myofibroblasts play central roles in fibrogenesis through their ability to synthesise increased quantities of ECM proteins.
Furthermore, these functionally differentiated proteins play distinct physiological roles and appear to be regulated differently within and between the haloarchaeal lineages in which they are found.
Our results also indicated the differentiated roles played by the mother, as a direct actor in the childbirth, and the father, as a direct witness.
Following malignant transformation, so termed cancer stem cells (CSC), endowed with the same properties as SSC (i.e. the ability to both self-renew and generate differentiated progenitors), play a major part in tumor initiation, therapy resistance and ultimately relapse.
11 The stratum corneum, which contains corneocytes and extracellular lipids secreted by differentiated keratinocytes, plays a vital immunologic role in the body, acting as a barrier against the entry of chemicals and microbes from the environment and protecting the body from dehydration.
For example, last year the Lego Group, after two decades of marketing almost exclusively to boys, introduced the new "Friends" line for girls after extensive market research convinced the company that boys and girls have distinctive, sex-differentiated play needs.
In the past few decades, as networks have become less differentiated, issuers have started playing a bigger role for consumers in the credit card world.
Neutrophils are short lived, terminally differentiated leukocytes that play a critical role in the destruction of invading bacteria and fungi.
