Simon Higlett's concave floor set helps create differentiated playing areas for the moments when scenes happen simultaneously and overlap.
For example, last year the Lego Group, after two decades of marketing almost exclusively to boys, introduced the new "Friends" line for girls after extensive market research convinced the company that boys and girls have distinctive, sex-differentiated play needs.
Differentiated chondrocytes play critical roles in endochondral ossification by producing factors such as Vegfa and IHH that signal to osteoblasts in adjacent perichondrium.
Differentiated myofibroblasts play central roles in fibrogenesis through their ability to synthesise increased quantities of ECM proteins.
Furthermore, these functionally differentiated proteins play distinct physiological roles and appear to be regulated differently within and between the haloarchaeal lineages in which they are found.
Following malignant transformation, so termed cancer stem cells (CSC), endowed with the same properties as SSC (i.e. the ability to both self-renew and generate differentiated progenitors), play a major part in tumor initiation, therapy resistance and ultimately relapse.
We analyze the differentiated role played by traditional R&D determinants in driving research and development.
Our results also indicated the differentiated roles played by the mother, as a direct actor in the childbirth, and the father, as a direct witness.
11 The stratum corneum, which contains corneocytes and extracellular lipids secreted by differentiated keratinocytes, plays a vital immunologic role in the body, acting as a barrier against the entry of chemicals and microbes from the environment and protecting the body from dehydration.
Neutrophils are short lived, terminally differentiated leukocytes that play a critical role in the destruction of invading bacteria and fungi.
A fundamental role in establishing and maintaining the post-mitotic state of differentiated cells is played by cyclin-dependent kinase inhibitors (CDKIs) such as p21, p27 and p57 that function by coupling cell cycle arrest and cell differentiation [3].
