Thus, the Sox17-induced bronchiolar-like structures contained a mixed population of cells that expressed CCSP, Foxj1, Sca-1, CCSP+/Sca-1+, and CCSP+/proSP-C+, consistent with reprogramming of progenitor cells along several differentiated pathways.
Figure 4A presents a Venn diagram of the differentiated pathways for each population pair.
Already during fetal development sex steroids permanently organize neuronal pathways involved in reproductive behavior and later, at puberty, sex steroids released form the gonads activate these differentiated pathways [ 5].
In recent years, the use of CGH led to the proposal of an integrated morphological/cytogenetic progression model for breast cancer (Vos et al, 2000; Buerger et al, 2001) with at least two different, parallel cytogenetic pathways: the well-differentiated and the poorly differentiated pathways.
Overall, the findings support the fourth hypothesis, that there are gender-differentiated pathways accounting for the effects of childhood adversities on adolescent depressive symptom formation.
In higher plants, however, most differentiated cells are able to transdifferentiate, i.e. start a new differentiation pathway.
Because NSCs are multipotent stem cells that can follow multiple differentiation pathways, using this differentiated cellular system may allow resident cell replacement and create an environment that supports and improves axon regeneration.
It will be interesting to determine whether this genetically differentiated immune pathway also has an association in defending RSV infection.
The loss of 16q thereby seems to represent the cytogenetic hallmark of the well-differentiated progression pathway, even though a subset of poorly differentiated tumours also revealed 16q-losses.
Early sexual differentiation of the developing brain is vulnerable to endocrine disruption by phytoestrogens which modify the organization of sexually differentiated neural pathways.
