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Growth at less than the maximum possible rate is not controversial for eukaryotic cells, particularly in the context of multicellular, differentiated organisms where unrestrained growth is an attribute of cancer.
Apoptosis, or programmed cell death, is a genetically controlled process, which maintains developmental morphogenesis (Vaux et al, 1994), and homeostasis of differentiated organisms by removing senescent, unneeded, or dangerous cells (Sternberg, 1997).
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It is only the interactions among them under normal conditions that lead to a complex, organized, integrated differentiated organism.
Notably, the finding of significant AS in the intron-rich pathogenic unicellular fungus Cryptococcus neoformans [ 3] demonstrates that widespread AS is not restricted to multicellular or highly-differentiated organisms.
The heart was long viewed as a postmitotic terminally differentiated organ, in which the number of cardiomyocytes at birth is constant throughout the lifespan of the organism.
A fundamental step in evolution was the transition from unicellular to differentiated, multicellular organisms.
If undifferentiated multicellularity is so easy to evolve in eukaryotes, then why did it take so long for fossils of differentiated multicellular organisms to appear in the fossil record?
We added the following as the last paragraph of the Discussion section: "If undifferentiated multicellularity is so easy to evolve in eukaryotes, then why did it take so long for fossils of differentiated multicellular organisms to appear in the fossil record?
C. elegans is a differentiated multicellular organism with a nervous system, reproductive organs, and digestive apparatus.
The mid-gestation embryo provides an overview of the entire organism showing well-differentiated organs and tissues resembling those of the adult in their basic design.
Amastigotes within tissue specimens can be differentiated from fungal organisms because they do not stain positive with periodic acid-Schiff, mucicarmine, or silver stain [ 24].
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CEO of Professional Science Editing for Scientists @ prosciediting.com