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BLCs are highly proliferative, genetically unstable, poorly differentiated, often grade III carcinomas [ 12, 13] and preferentially metastase in the brain and lungs [ 14].
However, there are also cases where crops and their wild relatives are genetically differentiated, often belonging to different species or differing in ploidy level.
High-level MSI colon cancers are commonly poorly differentiated, often presenting with a mucinous or mixed histology (Ward et al, 2001; Shia et al, 2003).
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Cells that mutate or commit to a specialized function (differentiate) often undergo conversions that are effectively irreversible.
For a long time, the most important inflammatory demyelinating diseases of the central nervous system (CNS), for example, multiple sclerosis (MS) and neuromyelitis optica (NMO), were extremely hard to differentiate, often with severe consequences for affected patients.
These bodies are the final ESC population that has the potential to give rise to all the cell types of adult tissues and have been described as the developmental equivalent of the egg cylinder-stage mouse embryo, with an outer endodermal layer and a core of differentiating cells, often comprised of epithelial-lined cavities [52].
Unlike previous studies [ 1, 2], we used MALDI-TOF to differentiate the often pathogenic Acinetobacter baumanii from low-pathogenic species.
Public transport planning is mainly done by transport associations often differentiated into road and rail public transport.
They noted that patients often differentiated between sleep quality and sleep quantity with the former being more descriptive (i.e., disturbed sleep, poor quality sleep, a feeling of being non-rested) and the latter being more quantitative (i.e., the number of hours a patient reported sleeping or being in bed, number of awakenings).
As a result, the typologies are often poorly differentiated.
Distinctions between nearby functional regions that are conflated in low resolution data can often be differentiated at higher resolution (e.g. [12], [18]).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com