We need to explore alternative models of observation such as differentiated observation, peer observation, lesson study and what I refer to as the "catchphrase model" of observation.
The differentiated observation of DWI parameters increased the information obtainable from imaging and provide additional parameters that can be introduced to large-data analysis.
Even under such modifications, the approximation of possible attractor points requires the presence of at least one non-differentiated observation in the computational formula.
The large amount of chondroid matrix that can be present in these tumours and the relatively scant malignant cells, even when the cells are poorly differentiated, makes this observation easy to comprehend.
Remarkably, there are over 20,000 MER20s in the human genome and many located near genes expressed in differentiated stromal cells (unpublished observations: V.J. Lynch, R. Leclerc, and G.P. Wagner).
As expected based on previous observations with differentiated Th17 cells in vitro, these cultures exhibited limited IFN-γ production.
We suggest that each Rhizophagus isolate harbors a population of differentiated genomes, based on observations from the two approaches presented in this study.
The solid tumors or small round blue cell tumors used have been of different tissues of origin, and could be differentiated easily by microscopic observations as well as by gene expression analysis.
Thus, as opposed to observations in differentiated astrocyte-targeted Tsc1 or Tsc2 mouse models, deletion of either Tsc1 or Tsc2 in distinct embryonic undifferentiated neural progenitors seems to result in overlapping phenotypes.
On the basis of our in vivo observation that MET-depleted tumors were more differentiated and our in vitro observation that murine C2C12 cell differentiation led to loss of chemotactic responsiveness to a SDF-1 gradient (Supplementary Figure 2), we speculated that the differentiation process influences the expression and/or functionality of the MET and CXCR4 receptors.
