Sentence examples for differentiated lymphocytes from inspiring English sources

In 6 out of 8 patients with B cell CLL, histopathology of lymph nodes showed infiltration with well differentiated lymphocytes and in all T cell lymphomata, the infiltrating cells were poorly differentiated.

The CD45RBlow CD62Llow CD4 T cells used here to transfer immunity are frequently described as both "memory" cells responsible for long-lasting immunity and confusingly, "effector" cells – cytokine-producing terminally differentiated lymphocytes [31].

Lymphoproliferative syndrome with well differentiated lymphocytes and moderate lymphocytosis in the peripheral blood includes a heterogeneous group of disorders, that present often difficulties in classification.

However, there have been no reports of similar genotoxicity in any clinical study manipulating differentiated lymphocytes, and T cells have been shown to resist retroviral-mediated transformation (Newrzela et al, 2008).

Moreover, terminally differentiated lymphocytes and plasma cells have shortened telomeres with drastically reduced replicative capacity [ 10], and therefore therapeutic approaches aimed at targeting cell division are also likely to fail.

"Mature" B-cell and B-mixed tumours showing capping surface Ig with Fc and/or C2 receptors correlated well with a nodular growth pattern, and consisted of what Rappaport (1966) calls "poorly differentiated" lymphocytes equivalent to the "small cleaved" cells as defined by Lukes and Collins (1975).

Although still poorly understood, the cross-talk between Deltex protein 1 (DTX1) and the evolutionary conserved Notch and NFkappaB signaling pathways [ 87, 88] allows the normal development and maturation of differentiated lymphocyte populations in hematopoietic and lymphopoietic organs in mammals.

A simple paradigm would assume that chronic autoimmune diseases, which depend on long-lived and highly-differentiated lymphocytes, are a high energy-consuming state susceptible to metabolic manipulations.

Within the B-lymphocyte system it is possible to identify subpopulations responsible for Burkitt's tumour, follicular (nodular) lymphomas, lymphocytic lymphomas of intermediate differentiation and well differentiated lymphocytic lymphomas.

As part of the NIH Mouse Regulome Project, we here combined DNaseI hypersensitivity, ChIP-seq, and ChIA-PET technologies to map the promoter-enhancer interactomes of pluripotent ES cells and differentiated B lymphocytes.

Previous reports of reprogramming terminally differentiated B lymphocytes in mice required the addition, or knock-down, of cellular identity-associated transcription factors and used a doxycycline-inducible expression system [17].