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ES cells can also be differentiated into specific lineages by coculture with other cells.
However, stem cells must be differentiated into specific mature cells prior to implantation (direct implantation may lead to tumour formation).
We discuss how hESCs are derived, characterized, and differentiated into specific cell lineages, and we summarize the characteristics of the 500 hESC lines reported to date.
However, in order to achieve successful regeneration of tissues or organs based on the tissue engineering concept, several critical elements should be deliberately considered including biomaterial scaffolds that serve as a mechanical support for cell growth, progenitor cells that can be differentiated into specific cell types, and inductive growth factors that can modulate cellular activities.
The first field is regenerative medicine, where iPS cells are differentiated into specific cell types that are transplanted into the patient for curative purposes.
In addition, iPSCs generated from patients could be differentiated into specific cells expressing specific phenotypes as a disease model to use efficient drug screening for incurable diseases.
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Human embryonic stem cells [hESCs] are able to differentiate into specific lineages corresponding to regulated spatial and temporal signals.
Bointerface mediated physical cues have been found to be able to guide stem cells to differentiate into specific cell lineages.
For SCI and MS patients, the capacity of hESCs to differentiate into specific neuronal lineages through effective induction is highly encouraging.
The researchers then attempted to see if the cells, which they labeled multipotent adult germline stem cells (maGSC), would differentiate into specific types of body cells.
Development is thought to go just one way: Stem cells differentiate into specific types of cells, but the reverse isn't supposed to happen.
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