Conversely, any transcriptional regulator expressed only in dHbl or dHbm neurons could only function as an effector of that specific differentiated identity, downstream of whatever factors mediate fate selection.
Because most of the cells expressing 76B>GFP reside outside the Dome-MESO boundary, interspersed in the cortex, and the double positives with either Dome-MESO (Fig. 2A) or the Pro-PO/Nim C (Fig. 2B,C) are rare, they most likely represent the transitional precursors that are derived from the medullary zone progenitors, but have not yet assumed a final differentiated identity.
When new states are formed by amalgamating diverse regional entities into a single and centralized one, the earlier, older and differentiated identities are expected to be discarded in favour of the new homogenized one.
Research shows that the healthy couple is close yet has autonomous and differentiated identities [ 22], and the corresponding sexual-developmental task is to sustain pleasure [ 10].
If cells require accurate spatial and temporal regulation of homeobox gene expression during embryogenesis to acquire the proper differentiated state (identity), misexpression of homeobox genes could lead to failure of differentiation, loss of the differentiated state or adoption of an alternative cell identity (a homeotic transformation).
Matthew Dear, on the other hand, has established such vastly differentiated musical identities on either side of the organic/electronic divide that you might just begin to wonder if that divide even exists.
To allow a phenotypic change from a stem cell to a distinct differentiated cell, cell identity must become unstable at some point in differentiation.
Our study suggests that the vast majority of Treg cell lineage-specific elements are not conserved between mice and humans suggesting that during cellular differentiation, only a handful of epigenetic elements implement the core transcriptional program that underlies establishment of a differentiated Treg cell identity and function.
Moreover, S induced hindbrain identity in differentiated neuronal cells from NPs.
But at the same time, we've left behind a part of our identity that differentiated us from the rest of the NGO world and also held the possibility of something deeper and more meaningful.
In mammals, homologs of these proteins are important for maintaining stem cell pluripotency and the identity of differentiated cells [19].
