Conversely, any transcriptional regulator expressed only in dHbl or dHbm neurons could only function as an effector of that specific differentiated identity, downstream of whatever factors mediate fate selection.
Because most of the cells expressing 76B>GFP reside outside the Dome-MESO boundary, interspersed in the cortex, and the double positives with either Dome-MESO (Fig. 2A) or the Pro-PO/Nim C (Fig. 2B,C) are rare, they most likely represent the transitional precursors that are derived from the medullary zone progenitors, but have not yet assumed a final differentiated identity.
Our data support a model in which Esg acts in a circuit with Delta-Notch signaling to control the switch from stem/progenitor identity to differentiated cell identities (Fig 8).
This normal identity crisis, however, must be differentiated from identity diffusion, the pathology of identity characteristic for borderline patients and other severe personality disorders.
Matthew Dear, on the other hand, has established such vastly differentiated musical identities on either side of the organic/electronic divide that you might just begin to wonder if that divide even exists.
If cells require accurate spatial and temporal regulation of homeobox gene expression during embryogenesis to acquire the proper differentiated state (identity), misexpression of homeobox genes could lead to failure of differentiation, loss of the differentiated state or adoption of an alternative cell identity (a homeotic transformation).
To allow a phenotypic change from a stem cell to a distinct differentiated cell, cell identity must become unstable at some point in differentiation.
Our study suggests that the vast majority of Treg cell lineage-specific elements are not conserved between mice and humans suggesting that during cellular differentiation, only a handful of epigenetic elements implement the core transcriptional program that underlies establishment of a differentiated Treg cell identity and function.
Juxtaposing the bases upon which identities were differentiated in Mbekweni with Antananarivo suggests a contradictory set of possible implications for vulnerability to HIV in these study sites.
