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The MMR-deficient tumours have characteristic features like being poorer differentiated, having more inflammation, and a more proximal location (Kane et al, 1997; Ropponen et al, 1997; Cunningham et al, 1998b).
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Silk Ventures aims to be the best partner for international companies that have truly differentiated, have impactful technologies and want real results when they enter China.
The paradigm that all cardiomyocytes are terminally differentiated has been challenged.
In particular, the percentage of the largest (index) cancer that is Gleason grade 4 and/or 5 (poorly differentiated) has strong predictive value [ 2, 3].
Autologous ECs harvested from blood vessel, such as veins, are terminally differentiated, have limited proliferation potential, and lose their function during in vitro expansion [ 31].
Among the major molecular subtypes, basal breast carcinomas are poorly differentiated, have metastatic potential and poor prognosis, but respond relatively well to chemotherapy.
Specifically, cancers composed entirely of Gleason grade 3 (well-differentiated) have a > 95% chance of being cured by surgery.
Patients with poorly differentiated carcinoma had worse OS than patients with moderately differentiated or well differentiated carcinoma (7.3 months vs 16.7 months, vs 25.8 months, respectively; P = .014).014
There was a marginal correlation (P = 0.04) with histological grade with well-differentiated tumours having the highest HSP27.
Similarly there was some evidence that poorly differentiated tumours had a higher response rate than well-differentiated tumours (P=0.046).
Patients with well differentiated tumor had a better outcome than those with moderate/poorly differentiated tumor.
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