Histologically, in both PBP/MED1fl/fl and PBP/MED1ΔLiv mice, a majority of liver tumors was well to moderately differentiated HCC generally with trabecular pattern.
Since cardiomyocytes are terminally differentiated and generally incapable of replicating in the adult heart, their survival is critical for maintaining myocardial viability.
62– 64 Using this prostatic adenocarcinoma classification scheme, between 13% and 73% of tumor specimens were considered moderately differentiated or generally low-grade tumors.
It has been found that many nuclear genes comprise two or more major differentiated haplotypes, generally referred to as allelic dimorphism [ 10- 20].
However, odor perception and the threshold for sensory irritation are sometimes not clearly differentiated and generally exist on a concentration gradient, but may overlap, i.e., some individuals may detect the odor before perceiving eye irritation or vice versa.
Although the relative frequency of a specific neuronal cell type might be favored, differentiated populations generally contain several types of neurons, as well as astrocytes, oligodendrocytes, neural precursors and even non-neural cells.
For example, mammalian embryonic stem cells can differentiate into all three germ layers when they form a spherical structure called the embryoid body (EB), in which differentiated tissues generally appear without any signals given from the outside of the body.
However, the proportion of oligodendrocytes differentiating from hPSCs among the differentiated progeny is generally very low [ 17].
On the other hand, genes that are known to function in cell differentiation, morphogenesis and the formation of differentiated tissues were generally down-regulated by EWS-FLI1, consistent with the poorly differentiated ESFT phenotype.
Stem cells and differentiated cells are generally believed to be mostly quiescent whereas progenitors are proliferative.
