Thus the elevated constitutive expression of Irga6 found in vivo appeared to reflect a differentiated property of hepatocytes that, in common with other differentiated functions of these cells, is lost on in vitro culture [19] [21].
In the adult prostate, androgens are believed to act through the stromal androgen receptor (AR) to maintain a growth-quiescent gland [16], [17] and through the epithelial AR to elicit the secretory differentiated function of the prostatic epithelium [18].
Its complex role seems to promote invasiveness, while inhibiting androgen receptor-mediated gene induction at androgen response element-regulated genes associated with differentiated function of the prostate (Axlund et al, 2010).
The resultant tissue structure maintains differentiated function of the different cell types, express liver-specific proteins (e.g. albumin) and respond to inducers of CYP enzymes (e.g. TCDD) and mediators of inflammatory responses for up to 2 months in culture.
In order to maintain the phenotype expression and differentiated functions of stem cells, the simulated natural environment of the biomimetic material support has to provide the appropriate signals to the attached cells.
In this study, we investigated the effects of terpolymer molecular weight (Mw) on the mechanical property of these microcapsules and the differentiated functions of encapsulated hepatocytes.
Hepatocyte growth factor (HGF) is now considered to be a pluripotent factor and has been shown to stimulate the differentiated functions of hepatocytes, as well as their proliferation.
However, as these cells are unlikely to perform the normal differentiated functions of epithelium, there follows a period of cell division and redifferentiation, leading to a complete restoration of normal epithelial barrier function.
HK-2 cells show some differentiated functions of proximal tubule cells, but are functionally and morphologically not equivalent to primary cells [ 91, 116- 118], and the use of oncogenes is associated with safety concerns.
The present study was designed to determine whether PAHs can concomitantly affect differentiated functions of trophoblastic cells.
