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A great demand for prebiotics is driving the search for new sources of fructo-oligosaccharides (FOS) producers and for FOS with differentiated functionalities.
P. patens has only a primitive protophloem, and the increase in the SWEET genes here could be due to the recent genome duplication [ 70], without the new genes necessarily having acquired differentiated functionalities.
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Its system-on-a-chip, or SoC, designs fully integrate high-definition video processing, image sensor processing, audio processing and system functions onto a single chip, delivering exceptional video and image quality, differentiated functionality and low power consumption.
While getting to market more quickly at a lower cost is a huge advantage, there is an even more important advantage: Companies that focus on their core capabilities develop differentiated functionality, their "secret sauce," at higher velocity.
It is a tremendous competitive advantage to task those engineers with building differentiated business functionality while your competitors build services that do commoditized, undifferentiated heavy lifting, and then remain stuck with the maintenance of those services for years to come.
While directed differentiation and transcription factor-mediated conversion strategies have generated progenitor cells with multilineage potential, to date, therapy-grade engineered HSCs remain elusive due to insufficient long-term self-renewal and inadequate differentiated progeny functionality.
Functionality of differentiated EC was assessed by angiogenesis assay.
Hence, dynamic imaging has been commonly used to assess neuronal functionality in differentiated cultures, primarily using Ca2+-sensitive dyes [3], [19] Ca2+ indicators can be delivered to neurons either by single cell injection (electroporation: [20]; whole cell patch-clamp: [21]) or bulk loading [22].
Old differentiated cells lose their functionality while stem and progenitor cells dedicated to generating new differentiated cells lose their regenerative capacity [ 5, 6].
Different mutations of HBx exert differentiated effects on the functionality of HIF-1 α, however, the overall activity of HBx mutants appears to increase the expression and transcriptional activity of HIF-1 α.
It is now evident that the use of these factors during differentiation can not only better direct cell fate, but can in fact enhance the specification and functionality of the differentiated cells.
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