(B) Examples of differentiated nephron cell types, which display unique morphological features.
The whole cytogenetic and immunohistochemical pattern of tumours with 7p-gains, and to a lesser extent 5p-gains as well as 9q-losses (see also cluster in Figure 2), therefore puts them forward as putative examples of poorly differentiated tumours originating from well-differentiated tumours that have acquired a high degree of cytogenetic instability.
Of importance for the role of ICG-001 as a chemotherapeutic drug, studies suggest that CBP-driven transcription helps to maintain pluripotency whereas p300-driven transcription pushes cells toward a differentiated state [ 3, 12– 15]; examples of genes thought to be regulated by CBP vs. p300 are shown in Figure 1C.
The many common examples of mechanical differentiators in which a displacement is differentiated with respect to time include speedometers and generators.
Recent examples of confirmed sex-differentiated effects identified through human GWAS include schizophrenia with SNPs in RELN [Shifman et al., 2008], serum uric acid concentrations with SNPs in SLC2A9 [Döring et al., 2008], and waist-hip ratio with SNPs in LYPLAL1 [Lindgren et al., 2009].
5, 6 Nuclear immunopositivity for MDM2 and CDK4 appears to be restricted to well-differentiated liposarcoma/ALT, allowing separation from challenging examples of benign lipomas.
The expression levels of these genes gradually increased as ES cells differentiated into each lineage (see Supplementary data for examples of gene expression changes).
Figure 4 displays examples of high-MAF SNPs, genetically differentiated among Malawi cichlid lineages, mapped to miRNA target sites in 3′-UTRs.
Examples of low vascular density in a well differentiated colon carcinoma and high vascular density in a poorly differentiated colon carcinoma are shown in Figure 2. A positive correlation between the percentage of EC and immunohistochemical MVD assessment was observed.
Examples of ND cells are cells that have fully differentiated or cells that have died.
