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Following gene duplications, TvBspA paralogues differentiated dramatically.
Interestingly, under the same joining conditions (fixed temperature and annealing duration), the thickness of the Ti interlayer determined the concentration and distribution of the Si and C reactants in the resulting joint layer, and the respective diffusion distance of Si and C into the Ti interlayer differentiated dramatically during the short joining process (only 5 min).
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The ratio of PAX6+ cells differentiated from TZ1 dramatically declined at day 10 of differentiation compared to that of the control groups (Figures 2B and 2C).
Development of more differentiated podocytes in culture has dramatically increased our understanding of the molecular mechanisms regulating podocyte actin dynamics.
Results also show that expression levels of the ER chaperones, GRP78/BiP and GRP94, were dramatically elevated in differentiated EBs and ESCs in response to DHT.
In particular, the expression of ALDH5A1, which encodes aldehyde dehydrogenase 5 family, member A1, was significantly increased in committed luminal cells, whereas the expression of CCNE1, which encodes Cyclin E1, was dramatically decreased in differentiated basal cells.
This may occur under perturbation of ER homeostasis or overloading of protein folding stimuli, such as androgens, which act as an effective stress signal to exhaust prosurvival efforts, encourage protein misfolding in ESCs that contains ER as a minimal structure in undifferentiated stages, but dramatically expands in differentiated stages.
In myogenic differentiation conditions, MyoG expression dramatically increased (70 fold) during the first 24 hours before reaching a plateau whereas in trans-differentiated MSC it did not exceed 4 fold.
DNA damage signals produced dramatically different responses in differentiated and undifferentiated SH-SY5Y cells.
The NTCP mRNA level was low in HepaRG cells before induction when examined on days 5 and 10 after initial plating, but increased dramatically when the cells differentiated after induction.
We observed that in all the cell lines, this IAP was dramatically downregulated in FCS-differentiated cells compared with NS, independently of their irradiation status.
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