In vitro, SU3 cells grew as suspended spheres in the conditional media containing growth factors, but they attached to the walls of the culture dish and differentiated, displaying star-shaped, fusiform, and other morphologies in the culture media containing serum.
It may also be that responses follow the script of gender-differentiated display rules (i.e., culture of emotions).
Melanoma inhibitory activity/cartilage-derived retinoic acid-sensitive protein (MIA/CD-RAP) was cloned as a secreted protein from human melanoma cell lines and independently identified by differential display comparing differentiated with dedifferentiated chondrocytes.
In case of development and differentiation, differentiated cells display a stable, cell-type-specific methylation pattern, permanently switching off the expression of genes that are not essential for the respective cell type.
However, chondrocyte differentiated BMSCs display an endochondral phenotype, that is, can terminally differentiate and form a calcified matrix, leading to failure in long-term defect repair.
Recombinant cells were then differentiated to display endocrine features, in particular the formation of granule-like compartments.
The first observation indicates that C4-HI tumors are more differentiated and display more ductal-like structures than the original C4-HD tumors (Figure 1).
Differentiated VSMCs display contractile properties, whereas undifferentiated VSMCs are proliferative (Owens, 1995).
It is well established that embryonic stem cells (ESCs) and fully differentiated cells display widely different genomic methylation patterns [ 14].
Differentiated neurons display specific biochemical, physiological and morphological properties that apparently prevent them from further cell division.
Clinical findings indicated that Src activity is highest in moderate to well-differentiated colonic lesions, whereas poorly differentiated carcinomas display Src kinase activity similar to normal colonic mucosa.
