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The prognostic significance of biclustered patient groups was observed in well-, moderandly- and poorly- differentiated disease.
It remains unclear whether treatment of SpA at an undifferentiated stage influences the subsequent development of irreversible differentiated disease.
Premenopausal patients with invasive or poorly differentiated disease had significantly higher prolactin levels than those with non-invasive disease.
These findings are consistent with previous reports that suggest that Trop-2 overexpression identifies biologically aggressive phenotypes and poorly differentiated disease [ 24, 28- 31].
Distant recurrence has been associated with large tumor size, poorly differentiated disease, and nodal involvement [ 10], and these factors are believed to be correlated also with late metastasis.
The mRNA expression levels of PTP4A3/PRL-3 were statistically significantly different between HCC and normal liver specimens (5.29 ± 1.43 vs. 3.86 ± 0.76, P = 0.0035, Fig. 3b, left), PTP4A3/PRL-3 was more highly expressed in poorly differentiated disease than in well-differentiated disease (6.21 ± 2.25 vs. 4.17 ± 1.70, P < 0.0001, Fig. 3b, right).
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The empirical global Fst distribution is shown in Figure 3 along with the 4 most highly differentiated disease-associated SNPs (i.e. SNPs with uncorrected P values < 0.1).
Some risk factors of late recurrence have been reported, including rectal location of the cancer, early stage at diagnosis, neoadjuvant (chemo radiation therapy for rectal cancer, pathologically well-differentiated disease, and low venous invasion [10 13].
Poorly-differentiated disease with a high proliferative index can result in more rapidly progressive disease and early mortality.
Figure 4 shows risk allele frequencies across populations and the two Fst matrices for the most highly-differentiated disease SNP rs10761659, a variant associated with Crohn's disease.
Well-differentiated liposarcoma and dedifferentiated liposarcoma are considered to be a disease spectrum with low histologic features favoring the well-differentiated disease while the areas of dedifferentiation may closely resemble a high-grade, spindle cell-shaped sarcoma.
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