"differentiated derivatives" is a correct and usable phrase in written English.
It refers to a specific type of financial derivative that has been modified or customized for a particular purpose. Example: "The investment company offers a range of differentiated derivatives to suit the diverse needs of their clients. These innovative products allow investors to manage their risks more effectively in volatile markets."
For the detection of differentiated derivatives, hES cell-derived EBs were plated on gelatin-coated 12-well plates to allow them to adhere, grown in DMEM (Invitrogen) containing 10%FBS (HyClone, Logan, UT) or Primary Neuron Growth Media (Lonza) to induce further differentiation for 14 days, and fixed in 4% paraformaldehyde followed by immunocytochemical analyses.
Additionally, the undifferentiated cells and differentiated derivatives of the TGCT-derived cell line NT2-D1 were analysed.
At this point, it is still unclear whether such differences affect only culture and differentiation behavior or may extend to functional properties of differentiated derivatives.
Notably, recent data support the concept that hESCs and their differentiated derivatives possess immune-privileged properties [ 1], suggesting that cells derived from hESCs may provide a potential tool for the induction of immunotolerance [ 2].
The pluripotent developmental potential of hPSCs and the success of transplanting their differentiated derivatives in animal disease models demonstrated the principle of using hPSC-derived cells as a regenerative source for transplantation therapies for human diseases.
We therefore investigated adhesion, cytoarchitecture and activation status of primary human monocytes and their differentiated derivatives, macrophages, on diamond-like coated glass coverslips using immunofluorescence technique.
In addition, up-regulation of myelin basic protein (MBP), which is enriched in oligodendrocytes, was also observed by qPCR (Fig. 1E), suggesting a possible existence of oligodendrocytes in the differentiated derivatives.
In addition, the mitochondrial function of Terc/iPSCs and their differentiated derivatives is severely impaired, while the mitochondrial function in Terc−/− ntESCs is considerably improved (Le et al., 2014).
For purposes of cell replacement therapies, a particularly concerning feature of culture adapted cells is the ability to form teratocarcinomas tumors that in addition to differentiated derivatives contain a remnant pool of undifferentiated stem cells, which can be placed back into culture and grown as hPSCs (Andrews et al., 2005; Blum and Benvenisty, 2009).
Even if scientists do not use iPS cells themselves for transplants but instead use differentiated derivatives of iPS cells, the risk of patients getting malignant cancers cannot be ignored.
If the starting population of cells are heterogeneous, their differentiated derivatives may also be heterogeneous.
