After in vitro exposure to Infliximab, there was a lack of effector cells, suggesting that this drug might block the lineage pattern of differentiation (naive → memory → effector → terminally differentiated cells), as a consequence of expansion and activation inhibition.
The three neurofilament genes (NF-L, NF-M, NF-H) were differentially expressed in the undifferentiated and differentiated conditions, possibly as a consequence of being independent transcription units and hence were differentially regulated [26].
The number of DNA hexamer (TTAGGG n repeats is reduced during each cell division in differentiated cells, and as a consequence telomere length (TL) often decreases in most differentiated cells throughout the lifespan of the organism [ 1].
This differentiated growth performance, as a consequence, has widened income and inequality gap between the two regions (Hang Chuon 2011).
This may indicate an active control of the neuroendocrine phenotype in tumors but also raises the question as to whether an abnormal phenotype (i.e. less well-differentiated tumor) could occur as a consequence of a disruption in the TFs (e.g., through methylation-mediated repression) that co-ordinate the neurodevelopmental pathway.
As a consequence, differentiated somatic cells undergo progressive telomere shortening with cell division, which limits their proliferative capacity and has thus been proposed as a tumor suppressor mechanism (Wright et al., 1996).
The first wave, or initiation stage, of apoptosis involves the death of a small population of differentiated MECs, and probably occurs as a consequence of changes in systemic hormones and/or mechanical forces.
Accordingly, the significant FIS values found within populations C and D may stem from a Wahlund effect involving the resurgence of genetically differentiated seed sources rather than as a consequence of the mating system, which was found to be highly outcrossing compared with populations A and B (see below).
As a consequence, a differentiated assessment of PSF + TOF and PSF with regard to varying TBR is required.
It is hypothesised that differentiated cancer cells can become CSCs as a consequence of EMT, allowing them to migrate, metastasize and survive chemotherapy [ 7, 14].
