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In contrast, genes in cluster F (202/154) transiently increase from stages IIb to V and could correspond to more differentiated, actively-dividing spermatogonia and early spermatocytes that accumulate during the course of the reproductive cycle.
The alkaline phoshatase activity in control sections shows that osteoblasts have differentiated and are actively involved in the ossification process.
U937 cells were chosen to recapitulate the behavior of differentiated monocytes that infiltrate actively inflamed intestinal tissues.
The result indicates that German-speaking consumers actively use differentiated and evaluative words to describe food-evoked emotions.
By looking at the case of La Toma in the Alto Cauca region, I conclude that the country's previous two presidencies have actively promoted differentiated access to and control over land-based resources, excluding Afrodescendant communities from accessing the environmental goods in their territories while favouring private actors.
Although hepatocytes are fully differentiated, they can still actively proliferate by self-duplication in response to external stimulation by specific humoral factors, including cytokines, growth factors and bile acids (Michalopoulos & DeFrances 1997; Taub 2004; Huang et al. 2006).
The decrease in the Mcm2/Ki67 ratios with increasing grade reflects a shift in the tumour cell population from a predominantly nonproliferating licensed state in differentiated tumours to an actively cycling state in poorly differentiated tumours (median grade 1: 4.13, grade 2: 2.56, grade 3: 1.85; P<0.001).
In actively dividing differentiated cells, with each cell division, a small amount of DNA is necessarily lost at each chromosome end, resulting in ever-shorter telomeres and altered telomere structure, eventually leading to the cessation of cellular proliferation (Blackburn 2000; Weinert and Timiras 2003).
This ability to move from quiescent and fully differentiated epithelial cells to actively proliferating multipotent cells led Evans et al. [7] to deem these Clara cells "facultative progenitor cells," as they are capable of but not limited to behavior indicative of a stem cell.
Moreover, in in vivo lesion sites of injured brains, TuJ-positive neuron subpopulations generally survived or actively trans-differentiated into neurons after Oct4/ATSC engraftment (Fig. 7A).
The pathognomonic features of this syndrome are found in bone marrow aspirates: numerous, well-differentiated macrophages (or histiocytes) actively phagocytosing hematopoietic elements.
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Justyna Jupowicz-Kozak
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