MS consist of a group of differentiated muscle fibers, called intrafusal fibers, surrounded over the central part by a fusiform capsule filled with a highly viscous fluid.
Interestingly, the series of WDTC analysed by Wreesmann et al (2002) was only composed of papillary tumours, a group of differentiated thyroid cancers which is characterised by molecular and chromosomal aberrations distinct from those that were ascertained to FTC development.
There appear to be a group of poorly differentiated samples, a group of well- and well-intermediately differentiated samples, and a third group containing mainly intermediately-poorly differentiated in situ cases.
When we analyzed differentiation status of these HCC cell lines according to HNF1α, 3α, 3β, 4α and 6 expressions, HepG2, Hep3B, PLC/PRF-5 and Huh7 formed a group of well differentiated cell lines, whereas others formed another subgroup of poorly differentiated cell lines (E. Erdal et al.; unpublished data).
To investigate the immunohistochemical expression (IHCE) of selected keratins in primary cutaneous and mucosal melanoma (pM), and metastatic melanoma (metsM) of the head and neck and to compare their expression to a group of undifferentiated/poorly differentiated tumors of the same anatomic region.
It remained to be elucidated whether CD133-positive HCCs were indeed of stem cell origin or they were just a group of poorly differentiated cells acquiring an embryonic marker.
Interestingly, we found a group of products, clearly differentiated from the rest by polarity, composed almost exclusively by proteins with many transmembranal segments (not shown).
Clinical outcomes in a group of stage IV, well-differentiated patients with NETs with small bowel primaries undergoing cytoreductive surgery and multidisciplinary management at a single center were evaluated.
CPKs belong to the CDPK/SnRK superfamily of protein kinases and represent a differentiated group of protein kinases found in plants, algae and protists [ 34- 36].
