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Instead of considering many pairwise comparisons for each locus, GSFST allows us to examine how differentiated a given group is at a given locus compared to all other groups, and relative to the rest of the chromosome.
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While trypanosomes regulate mRNA abundance to effect the major changes accompanying differentiation, a given differentiated state appears transcriptionally inflexible.
As elaborated in [4], the use of such binary datasets has two major limitations: (1) true-negative interactions and missing values are not differentiated, and (2) a given compound-target interaction is treated as a binary on off relationship, although it is more informative to use a continuous value that quantifies how strongly a compound binds to a target.
De-differentiation signifies the withdrawal of cells from a given differentiated state into a stem cell-like state, which confers pluripotency, a process that precedes re-entry into the cell cycle [3].
The last problem is to find a path differentiated scheme to induce a given target link-flow distribution while requiring a minimum number of sensors.
The main tenet of functionalism is that scientific analysis and explanation must focus on the functional integration of the differentiated component parts of a given structure or whole.
Cell reprogramming signifies the withdrawal of cells from a given differentiated state into a stem cell-like state, a process that precedes re-entry into the cell cycle [13].
The current definition of TSCs implies their potential to provide differentiated cells specific for a given tissue.
Therefore it can be hypothesized that the repertoire of proteins associated with CLDs has a functional impact on the metabolism of a given differentiated cell type.
This notion is consistent with the positive correlation between the higher incidence of differentiated cancer cells in a given tumour and favourable prognosis [ 3, 6, 7].
These results are in good agreement with data from similar studies [ 16, 41], and suggest that a significant fraction of cytoskeletal genes were not or very lowly expressed in our samples, consistent with the concept that only part of the genome is usually expressed in a given differentiated cell line or tissue [ 42].
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