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This market is growing really fast; I think there will be a lot of room for us to differentiate over time," he continues.
Although we have demonstrated engraftment of MDSC in the injury site, it remains to be determined whether MDSC would continue to differentiate over time.
Additional studies are needed to fully elucidate the role of microglia within the glioma and see whether different populations differentiate over time, possibly correlating with a different outcome of the disease.
MSCs, when are on a stiff substrate and in large numbers, tend to spontaneously differentiate over time into osteoblasts, and this process may be speeded by the overexpression of an important transcriptional factor, Foxc2 [ 39].
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It has been proposed alternatively that a proportion of these low-grade invasive tumours might de-differentiate over time into more aggressive, less well differentiated tumours (Tabár et al., 1999), although this was not found in another screening programme (Hakama et al., 1995).
It has been proposed alternatively that a proportion of these low-grade invasive tumours might, if not detected, de-differentiate over time into more aggressive, less well-differentiated tumours.
Together, these studies show that if pluripotent cells are allowed to differentiate over long periods of time in complex 3-D in vivo environments, maturation of various cell types can be enhanced (Fig. 1).
Previously, it was discussed how the observed vertical movements differentiated over time were similar to the barometric variations observed at SN-3 and STG200; here, we discuss the observed barometric variations related to a time integral.
Bayesian phylogenetic analysis on the 55 pol sequences revealed the existence of a main clade statistically supported, introduced in Rome before 2000 and differentiated over time into two sub-clades (A and B) well defined for year of start of circulation (2000 and 2005).
Cells were allowed to grow and differentiate over a relatively short period of time (7 days), after which cultures were fixed and stained to visualize nuclei with Topro-3 as well as cell bodies and extending processes with neurofilament immunostaining.
- The EBs can continue to grow and differentiate spontaneously over time to generate a wide variety of cell types.
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