Unlike neural stem cells, cancer cells were unable to differentiate and remained extensively DNA methylated at exon 2 of POLGA.
The regulatory mechanisms by which RANKL and its intracellular signaling pathways enable pre-OCs to differentiate have been extensively studied [ 8, 35, 36].
Under the regulation of systemic hormones, as well as local stromal epithelial interactions, these cells proliferate extensively, differentiate during each pregnancy and lactation, and undergo apoptosis during mammary involution [ 2].
The hippocampus has differentiated into an extensively connected recurrent stage (CA3) followed by a feed-forward stage (CA1).
Twin studies have been used extensively to differentiate between environmental and hereditary risk factors for metabolic disease (3).
Fatty acid and protein molecular phenotyping are well recognized methods for typing bacteria and have been used extensively to differentiate bacteria, including Brucella strains [ 24, 31, 32].
It is used extensively to differentiate reactivation tuberculosis (TB), which is due to a remote infection, from disease caused by recently transmitted organisms.
Apparently, after the bottleneck associated with the first colonization of the Americas, which increased LD, genetic drift has acted extensively to differentiate American populations in their allele and haplotype frequencies as well as in their levels of LD.
After stimulation in culture, these cells produce a wide range of T-cell cytokines, undergo proliferation and differentiate to acquire an extensively activated phenotype resembling RA synovial T cells.
Being at the top of the hematopoietic hierarchy, HSCs divide infrequently, giving rise to transient-amplifying multipotent (MPPs) and lineage-restricted progenitors that proliferate extensively and differentiate toward mature blood cells.
