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Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment.
The cells after transduction stably expressed green fluorescence protein (GFP) and maintained the abilities to differentiate down osteogenic and adipogenic lineages.
Thus, both rodent and human SKPs generate skeletogenic cell types in culture, and the injured bone environment is sufficient to instruct SKPs to differentiate down an osteogenic lineage, in a fashion similar to the endogenous mesenchymal precursors.
They are a derivative of BG01 cells with karyotypic abnormalities (49, +12, +17 and XXY) which retain embryonic stem cell markers and characteristics, and the ability to differentiate down a neural lineage [43].
Whether BCR stimulation inhibits the induction of IL-10 competence by inducing B cells to mature or differentiate down a divergent pathway or diverts intracellular signaling is unknown.
BG01V cells are a derivative of BG01 cells with karyotypic abnormalities (49, +12, +17 and XXY) which retain embryonic stem cell markers and characteristics, and the ability to differentiate down a neural lineage [ 49].
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This finding was translated to 3D hydrogel structures: cells near the edge of 3D cube-shaped collagen constructs differentiated down an osteogenic lineage, and those at the center differentiated down an adipogenic lineage.
Three poxviruses (cowpox, vaccinia-MVA, and vaccinia-Lister) were identified and differentiated down to the strain level, despite over 98% identity between the vaccinia strains.
2 Although our model is general enough to allow the human population to be differentiated down to an individual level, 1 here we model the intervention strategies by dividing the human population into groups that either have the intervention or do not have it.
During development of the murine lens, fibre cells terminally differentiate – laying down a complex crystalline substructure that is devoid of nuclei and organelles, thus preventing light scattering and allowing normal lens transparency (Tholozan and Quinlan, 2007).
Proliferating cells then either down-regulate Pax7 in order to differentiate, or down-regulate MyoD and self-renew[43], [45], [51].
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