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Psoriasis lesions develop in response to interplay between lesion-infiltrating inflammatory cells and local KCs, which respond to cytokine signals by failing to differentiate completely and adopting a phenotype resembling that of proliferating basal-layer KCs [1,2].
These expression patterns support the hypothesis that CIS cells arise from immature fetal germ cells that fail to differentiate completely into normal spermatogonia (Skakkebaek et al., 1987).
Myeloproliferative Neoplasms (MPN) represent clonal proliferations of pathological haematopoietic stem cell, which have become independent from physiological growth control but retain the ability to differentiate completely into all hematopoietic lineages.
Of the 104 markers analysed, six loci (mCrCIR01C06, mCrCIR07B05, Cx6F03, CID0591, CID2493 and MEST473) were able to differentiate completely between the female and male parents and thus enabled unequivocal identification of the parent producing the 2n gamete for each triploid hybrid (Additional file 1).
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-Regeneration percentage (R): number of cultures that differentiated into completely developed shoots × 100/total number of cultured explants.
Partial least squares discriminant analysis differentiated almost completely between the metabolome of males and females (Fig. 3) and among flies of different ages (Fig. S2, Supporting information).
In many instances intercalary meristems function for only a short time and eventually completely differentiate into mature tissues.
The problem with MRI is believed to be that it cannot completely differentiate fibrosis from viable residual tumours.
At around two-six years of age, children may be unable to completely differentiate themselves from their environment, so they explain their experience through cause effect relations.
The clusters obtained for the tissue classes are strongly overlapped, indicating that the MR data will not, regardless of the chosen space partition, be able to completely differentiate the bony and soft structures.
However, to completely differentiate between maternal and fetal actions in this period will be virtually impossible when examining drug administration, which by necessity must be through the mother.
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CEO of Professional Science Editing for Scientists @ prosciediting.com